Browsing by Author "Maren, Stephen"
Now showing items 1-20 of 26
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Nagaya, Naomi; Acca, Gillian; Maren, Stephen (Frontiers in Behavioral Neuroscience, 2015)
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Cardona-Acosta, Astrid Mariela (2021-04-05)Rationale: There is evidence of increased use and abuse of alprazolam (Xanax; ALP) during adolescence, yet most available neurobiological evidence has been derived from studies using adult organisms. Objectives: This study ...
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Evemy, Carolyn Grace (2019-04-22)The purpose of this experiment was to examine the cognitive mechanisms by which an animal uses associations to learn about temporally ambiguous aversive events. Traditionally, associative learning using forwards conditioning, ...
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Goode, Travis D. (2018-06-22)Anxiety disorders are among the most common and debilitating forms of mental illnesses in society. Through greater understanding of the fundamental mechanisms of anxiety, as well as of the factors that lead to the persistence ...
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French, Kaitlyn Virginia (2018-05-03)Anxiety disorders are some of the most common and debilitating forms of mental illnesses in our society. Understanding the behavioral and brain mechanisms of anxiety is essential in the development of novel therapeutic ...
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Leong, Kah-Chung (2014-09-18)Recently studies have uncovered a wealth of evidence supporting the theory that different areas of the mammalian brain mediate different types of memory. Specifically, evidence suggests that memory does not exist as a ...
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Orsini, Caitlin A.; Yan, Chen; Maren, Stephen (Frontiers, 2013-12-13)After fear conditioning, presenting the conditioned stimulus (CS) alone yields a context-specific extinction memory; fear is suppressed in the extinction context, but renews in any other context. The context-dependence of ...
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Wang, Qian (2017-06-21)Exposure therapy is an effective treatment for posttraumatic stress disorder (PTSD). However, many patients experienced relapse of fear after treatment. Pavlovian fear conditioning and extinction are effective models to ...
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Goodman, Jarid (2016-08-05)A defining symptom of numerous human psychopathologies is the inability to control maladaptive behaviors—or “habits.” Extensive research using animal learning paradigms has led to exciting developments regarding the ...
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Giustino, Thomas; Fitzgerald, Paul; Maren, Stephen (PloS One, 2016)
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Jin, Jingji; Maren, Stephen (Scientific Reports, 2015)
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Acca, Gillian M (2017-07-10)Sex differences in stress and anxiety disorders are well reported in the clinical population. For instance, women are twice as likely to be diagnosed with post-traumatic stress disorder (PTSD) compared to men. This difference ...
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Jin, Jingji (2017-12-08)Exposure therapy for stress- and anxiety-related disorders is very effective, but fear return after treatment is not uncommon. During extinction, repeated exposure to a conditioned stimulus (CS) gradually decreases the ...
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Fitzgerald, Paul; Giustino, Thomas; Seemann, Jocelyn; Maren, Stephen (Proceedings of the National Academy of Sciences of the United States of America, 2015)
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Giustino, Thomas Francis (2019-06-04)Early intervention strategies (e.g., psychological debriefing and exposure therapy) are thought to rely on extinction-like mechanisms to reduce pathological fear. These therapies attempt to reduce or prevent the development ...
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Kim, Woo Seok (2021-04-06)In this study, I introduce an organ-specific scalable, multimodal, wireless optoelectronic device for precise and chronic optogenetic manipulations in vivo. When combined with an advanced, coil-antenna system and a ...
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Huddleston, Isabella J (2020-04-08)Humans and animals use environmental cues to determine appropriate defensive responses. Understanding the mechanisms of context-mediated fear responses is crucial, as the dysregulation of these processes are central to ...
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Binette, Annalise (2023-03-28)Fear extinction is a prefrontal-dependent process that promotes the suppression of learned fear. Unlike fear memory, extinction memory is less durable and sensitive to a variety of factors, including stress. This is ...
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Kim, Janice J (2014-12-08)The bed nucleus of the stria terminalis (BNST) is thought to be involved in the expression of fear to shock-associated contexts, but not to discrete conditional stimuli (CSs) paired with shock. Because context plays an ...
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Alcantara, Lyonna Francesca (2018-08-02)Approximately 13% of children aged 12-17 are diagnosed with major depressive disorder (MDD). This is particularly troubling since according to the World Health Organization, suicide is the second leading cause of death in ...